The Aging Human Heart
نویسندگان
چکیده
منابع مشابه
Myocyte turnover in the aging human heart.
RATIONALE The turnover of cardiomyocytes in the aging female and male heart is currently unknown, emphasizing the need to define human myocardial biology. OBJECTIVE The effects of age and gender on the magnitude of myocyte regeneration and the origin of newly formed cardiomyocytes were determined. METHODS AND RESULTS The interaction of myocyte replacement, cellular senescence, growth inhibi...
متن کاملThe Aging Heart.
Aging results in progressive deteriorations in the structure and function of the heart and is a dominant risk factor for cardiovascular diseases, the leading cause of death in Western populations. Although the phenotypes of cardiac aging have been well characterized, the molecular mechanisms of cardiac aging are just beginning to be revealed. With the continuously growing elderly population, th...
متن کاملCardiomyogenesis in the aging and failing human heart.
BACKGROUND Two opposite views of cardiac growth are currently held; one views the heart as a static organ characterized by a large number of cardiomyocytes that are present at birth and live as long as the organism, and the other views the heart a highly plastic organ in which the myocyte compartment is restored several times during the course of life. METHODS AND RESULTS The average age of c...
متن کاملImpact of aging on substrate metabolism by the human heart.
BACKGROUND Results of studies in experimental animals have shown that, with age, myocardial fatty acid metabolism decreases, and glucose metabolism increases. Whether similar changes occur in humans is unknown. METHODS Seventeen healthy younger normal volunteers (six males, 26 +/- 5 years) and 19 healthy older volunteers (nine males, 67 +/- 5 years) underwent positron emission tomography (PET...
متن کاملMolecular Cardiology Cardiomyogenesis in the Aging and Failing Human Heart
Background—Two opposite views of cardiac growth are currently held; one views the heart as a static organ characterized by a large number of cardiomyocytes that are present at birth and live as long as the organism, and the other views the heart a highly plastic organ in which the myocyte compartment is restored several times during the course of life. Methods and Results—The average age of car...
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ژورنال
عنوان ژورنال: Circulation: Cardiovascular Imaging
سال: 2017
ISSN: 1941-9651,1942-0080
DOI: 10.1161/circimaging.116.005899